Bibliography of Scientific Publications

The bibliography presented here is organized by the seven key areas of research that are part of the Myelin Repair Foundation's integrated research plan.

Roll over and click the image below to learn more about each area of the research plan.

Complete Bibliography (PDF) — Revised March 23, 2011.

1. Understanding how oligodendrocytes are normally generated from neural stem cells and how MS perturbs this process

Bai, Lianhua; Caplan, Arnold; Lennon, Donald; Miller, Robert H.. Human Mesenchymal Stem Cells Signals Regulate Neural Stem Cell Fate. Neurochemical Research (2007), 32(2): 353-362.

Bai L, Lennon DP, Eaton V, Maier K, Caplan AI, Miller SD, Miller RH. 2009. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia. Aug 15;57(11):1192-203.

Fyffe-Maricich SL, Karlo JC, Landreth GE, Miller RH. 2011. The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation. J Neurosci. Jan 19;31(3):843-50.

Kerstetter AE, Padovani-Claudio DA, Bai L, Miller RH. 2009. Inhibition of CXCR2 signaling promotes recovery in models of multiple sclerosis. Exp Neurol. Nov;220(1):44-56.

Miller, R. H.; Bai, L.. The Expanding Influence of Stem Cells in Neural Repair. Editorial. Annals of Neurology (2007), 61 (3): 187-8.

Miller, R. H.; Bai, L.. Cellular approaches for stimulating CNS remylination. Regen Med (2007), 2(5): 817-29.

Miller, Robert H.. The promise of stem cells for neural repair. Brain Research (2006), 1091(1): 258-264.

Svenningsen, A.F., Colman, D. R., and Pedraza, L. 2004. Satellite cells of dorsal root ganglia are multipotential glial precursors. Neuron Glia Biology 1:85-93.

Yang Y, Lewis R, Miller RH. 2011. Interactions between oligodendrocyte precursors control the onset of CNS myelination. Dev Biol. Feb 1;350(1):127-38.

2. Understanding the underlying mechanism of myelination and how it is perturbed in MS

Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA, Thompson WJ, Barres BA. 2008. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. Journal of Neuroscience 28:264-78.

Chan, J.R.; Watkins, T.A.; Cosgaya, J.M.; Zhang, C.Z.; Chen, L.; Reichardt, L.F.; Shooter, E.M.; Barres, B.A.. 2004. NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron 43(2):183-91.

Colman, D.R. 2004. Obedient and wayward synaptic behavior. Cell 116:766-7.

Balabanov, R; Popko, B.. Myelin Repair: developmental myelination redux? Nature Neuroscience (2005), 8:262-264.

Balabanov, Roumen; Strand, Krystal; Kemper, April; Lee, Ji Yeon; Popko, Brian.. Suppressor of cytokine signaling 1 expression protects oligodendrocytes from the deleterious effects of interferon-gamma. Journal of Neuroscience (2006), 26(19): 5143-5152.

Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo CJ, Barres BA. 2009. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A. Jan 13;106(2):641-6. Erratum in: Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6422.

Dugas, Jason C.; Ibrahim, Adiljan; Barres, Ben A.. A Crucial Role for p57Kip2 in the Intracellular Timer that Controls Oligodendrocyte Differentiation. Journal of Neuroscience (2007), 27(23): 6185-6196.

Dugas, Jason C.; Tai, Yu, Chuan; Speed, Terence, P.; Ngai, John; Barres, Ben A.. Functional genomic analysis of oligodendrocyte differentiation. Journal of Neuroscience (2006), 26(43): 10967-10983.

Dugas JC, Mandemakers W, Rogers M, Ibrahim A, Daneman R, Barres BA. 2008. A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinal motor neurons. J Neurosci. Aug 13:28(33):8294-305.

Emery B, Agalliu D, Cahoy JD, Watkins TA, Dugas JC, Mulinyawe SB, Ibrahim A, Ligon KL, Rowitch DH, Barres BA. 2009. Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell. Jul 10;138(1):172-85.

Fuller, M.L.; DeChant, A. K.; Rothstein, B.; Caprariello, A.; Wang, R.Z.; Hall, A.K.; Miller, R.H.. Bone morphogentic proteins promote gliosis in demyelinating spinal cord lesions. Annals of Neurology (2007), 62 (3): 288-300.

Gao, Limin; Macklin, Wendy; Gerson, James; Miller, Robert H.. Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retina. Developmental Biology (2006), 290(2): 277-286.

Gao, Limin; Miller, Robert H.. Specification of optic nerve oligodendrocyte precursors by retinal ganglion cell axons. Journal of Neuroscience (2006), 26(29): 7619-7628.

Gao, Limin; Miller, Robert H.. Cytokines and development of the nervous system. Cytokines and the CNS (2nd Edition) (2006), 93-112.

Gao, L; Miller, RH. Cytokines and the Development of the Nervous system. Cytokines and the CNS (2005), 2nd ed. pp93-113. Eds R. Ransohoff and E. Benveniste.

Hartline, D.; Colman, D.R.. Rapid conduction and the evolution of giant axons and myelinated fibers. Curr. Biol. (2007), 17:R29-R35.

Howng SY, Avila RL, Emery B, Traka M, Lin W, Watkins T, Cook S, Bronson R, Davisson M, Barres BA, Popko B. 2010. ZFP191 is required by oligodendrocytes for CNS myelination. Genes Dev. Feb 1; 24(3):301-11.

Koch, A.W., Farooq, A., Shan, W., Zeng L., Colman, D. R., and Zhou, M. M. 2004. Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics. Structure 12:793-805.

Lin, W; Harding, HP; Ron, R; Popko, B.. ER Stress Modulates the Response of Myelinating Oligodendrocytes to the Immune Cytokine Interferon-_. J. Cell Biol. (2005), 169: 603-612.

Lin, W.; Kemper, A.; Dupree, J. L.; Harding, H.P.; Ron, D.; Popko, B.. Interferon gamma Inhibits Central Nervous System Remyelination through a Process Modulated by Endoplasmic Reticulum Stress. Brain (2006), 129: 1306-1318.

Lin W, Kunkler PE, Harding HP, Ron D, Kraig RP, Popko B. Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma. Am J Pathol. 2008 Nov;173(5):1508-17.

Lin W, Popko B. 2009. Endoplasmic reticulum stress in disorders of myelinating cells. Nat Neurosci. Apr;12(4):379-85. Review.

Mi, S.; Miller, R. H.. Dissecting Demyelination. Nature Neuroscience (2007), 10(11): 1351-1354.

*Nair, A. and T. J. *Frederick, and S. D. Miller. 2008. Astrocytes in multiple sclerosis; A product of their environment. Cell. Mol. Life Sci. Published Online. (*Co-first authors)

Padovani-Claudio, Dolly A; Liu, Liping; Ransohoff, Richard M; Miller, Robert H.. Alterations in the oligodendrocyte lineage, myelin, and white matter in adult mice lacking the chemokine receptor CXCR2. Glia (2006), 54(5): 471-83.

Phillips, G.R., Florens, L., Tanaka H., Khaing Z.Z., Fidler L., Yates, J.R. 3rd, Colman, D.R. Proteomic comparison of two fractions derived from the transsynaptic scaffold. J. Neurosci. Res. (2005) 81:762-75.

Popko B: Epigenetic Control of Myelin Repair. Nature Neuroscience. 2008. 1(9):987- 988.

Roth, A.; Ivanova, A.; Colman, D.R.. New observations on the compact myelin proteome. Neuron Glia Biol. (2006), 2:15-21.

Shan, W., Yagita, Y., Wang, Z., Koch, A., Svenningsen, A.F., Gruzglin, E., Pedraza, L., Colman, D.R. 2004. The minimal essential unit for cadherin-mediated intercellular adhesion comprises extracellular domains 1 and 2. J Biol Chem. 279:55914-23.

Shapiro, L.; Love, J.; Colman, D.R.. Adhesion molecules in the nervous system: structural insights into function and diversity. Ann. Rev. Neurosci. (2007), 30:451- 474.

Teague Getts, M., D. Getts, A. P. Kohm, and S. D. Miller. 2008. The ER stress response as a therapeutic target in MS. Therapy. 2008. 5(5):631-640.

Traka M, Wollmann RL, Cerda SR, Dugas J, Barres BA, Popko B: Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS. J Neurosci. 2008 28(45):11537-11549.

Tsai, Hui-Hsin; Macklin, Wendy B.; Miller, Robert H.. Netrin-1 is required for the normal development of spinal cord oligodendrocytes. Journal of Neuroscience (2006), 26(7): 1913-1922.

Watkins T, Emery B, Mulinyawe S, and Barres B. Distinct stages of myelination regulated by gamma secretase and astrocytes in a rapidly myelinating CNS coculture system. Neuron. 2008 Nov 26;60(4):555-69.

3. Understanding how nodes of Ranvier and paranodes are normally formed and how they are perturbed in MS

Dupree, JL; Mason, JL; Marcus, JR; Stull, M; Levinson, R, Matsushima, GK; Popko, B: Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath. Neuron Glia Biology (2005), 1: 1-14.

Huang, JK; Phillips, GR; Roth, AD; Pedraza, L; Shan, W; Belkaid, W; Mi, S; Fex- Svenningsen, A; Florens, L; Yates, JR 3rd; Colman, DR.. Glial membranes at the node of Ranvier prevent neurite outgrowth. Science (2005), Dec 16, 310 (5755): 1813-7. Epub (2005), Nov 17.

4. Understanding the immune response in MS and how inflammation affects myelin repair

Bailey-Bucktrout, S. L., S. Caulkins, G. Goings, J. A. Fischer, A. Dzionek, and S. D. Miller. 2008. Cutting Edge: CNS plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis. J. Immunol. 180:6457- 6461 (PMID: 18453561).

Bailey, S. L., B. Schreiner, and S. D. Miller. 2008. CNS dendritic cells in inflammation and disease. In: Central Nervous System Diseases and Inflammation. (T. E. Lane, M. Carson, C. Bergmann and T. Wyss-Coray, eds.). Springer, New York, NY. Pp 263-275.

Bailey, Samatha L.; Carpentier, Pamela A.; McMahon, Eileen J.; Smith Begolka, Wendy; Miller, Stephen D.. Innate and Adaptive Immune Responses of the Central Nervous System. Critical Reviews™in Immunology (2006), 26(2):149-188.

Bailey, Samantha L.; Schreiner, Bettina; McMahon, Eileen J.; Miller, Stephen D.. CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE. Nature Immunology (2006), Volume Date 2007, 8(2): 172-180.

Bailey, S. L., B. Schreiner, and S. D. Miller. CNS dendritic cells in inflammation and disease. Neurochem Int. 2006. Jul;49(2):195-203.

Bailey, S. L., B. Schreiner, E. J. McMahon, and S. D. Miller. CNS myeloid dendritic cells presenting endogenous myelin peptides preferentially polarize CD4 + Th17 cells in relapsing EAE. (2007), Nat. Immunol. 8:172-180.

Balabanov, Roumen; Strand, Krystle; Goswami, Rajendra; McMahon, Eileen: Begolka, Wendy; Miller, Stephen D.; Popko, Brian. Interferon-_-Oligodendrocyte Interactions in the Regulation of Experimental Autoimmune Encephalomyelitis. J. Neurosci. (2007), 27(8): 2013-2024.

Begolka, W. S., E. J. McMahon, and S. D. Miller. 2006. Cytokines and immune regulation in the nervous system. In: Cytokines and the CNS (E. Benveniste and R. M. Ransohoff, eds.). CRC Press, New York. Pp. 137-162.

Blink SE, Miller SD. 2009. The Contribution of gammadelta T Cells to the Pathogenesis of EAE and MS. Curr Mol Med. Feb:9(1):15-22.

Carpentier, P. A., D. S. Duncan, and S. D. Miller. 2008. Pattern recognition receptors in CNS disease. In: Central Nervous System Diseases and Inflammation. (T. E. Lane, M. Carson, C. Bergmann and T. Wyss-Coray, eds.). Springer, New York, NY. Pp 131-152.

*Carpentier, P. A., D. S. Duncan*, and S. D. Miller. 2008. Glial Toll-like receptor signaling in central nervous system infection and autoimmunity. Brain Behav. Immun. 22:140-147. (*co-first authors).

Carpentier, P. A., M. Teague Getts, and S. D. Miller. 2008. Pro-inflammatory functions of astrocytes correlate with viral clearance and strain-dependent protection from TMEV-induced demyelinating disease. Virology. 375:24-36

Frederick, Terra J.; Miller, Stephen D.. Arresting autoimmunity by blocking _- arrestin 1. Nature Immunology (2007), Vol. 8, No. 8, 791-792.

Frederick, Terra J.; Miller, Stephen D.. Future of multiple sclerosis therapy; combining antigen-specific immunotherapy with strategies to promote myelin repair. Future Neurol. (2006), 1(4): 489-503.

Howard LM, Kohm AP, Castaneda CL, Miller SD. Therapeutic blockade of TCR signal transduction and co-stimulation in autoimmune disease. Curr Drug Targets Inflamm Allergy. 2005 Apr; 4(2):205-16.

Howard LM, Miller, SD. Immunotherapy targeting the CD40/CD154 costimulatory pathway for treatment of autoimmune disease. Autoimmunity. 2004: Aug; 37(5):411- 8. Review.

Lin, Wensheng; Bailey, Samantha L.; Ho, Hanson; Harding, Heather P.; Ron, David; Miller, Stephen D.; Popko, Brian.. The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. Journal of Clinical Investigation (2007), 117(2): 448-456.

Luo X, Pothoven KL, McCArthy D, DeGutes M, Marin A, Getts DR, Xia G, He J, Zhang X, Kaufman DB, Miller SD. 2008. ECDI-fixed allogeneic splenocytes induce donorspecific tolerance for long-term survival of islet transplants via two distinct mechanisms. Proc Natl Acad Sci USA Sep 23;105(38):14527-32.

Martin AJ, McCarthy D, Waltenbaugh C, Goings G, Luo X, Miller SD. 2010. Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation. J Immunol. 2010 Sep 15;185(6):3326-36.

*McMahon, E. J., S. L. Bailey*, and S. D. Miller. 2006. CNS dendritic cells: critical participants in CNS inflammation? Neurochem. Intl. 49:195-203. *Co-first authors.

McMahon, E. J.; Bailey, S. L.; Vanderlugt-Castenada, C. L.; Waldner, H.; Miller, S. D.. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nature Med. (2005), 11: 335-339. (highlighted in Nature Med. News and Views 11: 252- 253). http

Miller, S. D., E. J. McMahaon, B. Schreiner, and S. L. Bailey. 2007. Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis. Ann. N.Y. Acad. Sci. 1103:179-191.

Miller, Stephen D.; Turley, Danielle M.; Podojil, Josephe R.. Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease. Nature Reviews: Immunology (2007), Vol. 7, 665-677.

Minter, L. M.; Turley, D. M.; Das, P.; Shin, H. M.; Joshi, I.; Lawlor, R. G.; Cho, O. H.; Palaga, T.; Telfer, J. C.; Kostura, L.; Fauq, A. H.; Simpson, K.; Such, K. A.; Miele, L.; Golde, T. E.; Miller, S. D.; Osborne, B. A.. Inhibitors of -secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nature Immunol. (2005), 6: 680-688.

Podojil, Joseph R.; Kohm, Adam P.; Miller, Stephen D.. CD4+ T Cell Expressed CD80 Regulates Central Nervous System Effector Function and Survival during Experimental Autoimmune Encephalomyelitis. Journal of Immunology (2006), 177: 2948-2958.

Podojil JR, Miller SD. 2009. Cross-linking of CD80 on CD4+ T cells activates a calcium-dependent signaling pathway. J Immunol. Jan 15;182(2):766-73.

Podojil JR, Miller SD. 2009. Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy. Immunol Rev. May;229(1):337-55. Review.

Podojil, Joseph R.; Miller, Stephen D.. Immunopathological mechanisms in multiple sclerosis. Drug Discovery Today: Disease Mechanisms (2006), Vol. 3, No. 2.

Podojil JR, Turley DM, Miller SD. 2008. Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease. Adv Exp Med Biol. 640:234-51. Review.

Smith, C. E. and S. D. Miller. 2006. Multi-peptide coupled-cell tolerance ameliorates ongoing EAE associated with multiple pathogenic autoreactivities. J. Autoimmunity. 27:218-231.

Turley DM, Miller SD. 2009. Prospects for Antigen-Specific Tolerance Based Therapies for the Treatment of Multiple Sclerosis. Results Probl Cell Differ. Jan 8.

Turley, D. M. and S. D. Miller. 2007. Peripheral tolerance induction using ECDIfixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of EAE. J. Immunol. 178:2212-2220.

Zhang, H., J. R. Podojil, X. Luo, and S. D. Miller. Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. J. Immunol. 2008 Oct 1;181(7):4638-47.

5. Understanding how the Blood Brain Barrier is affected in MS and its role in the disease

Daneman R, Zhou L, Agalliu D, Cahoy JD, Kaushal A, Barres BA. 2010. The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS One. Oct 29;5(10):e13741.

Daneman R, Zhou L, Kebede AA, Barres BA. 2010. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. Nov 25;468(7323):562-6.

6. Development of better animal models for study of MS and remyelination

Caprariello AV, Miller RH, Selkirk SM. 2009. Foamy Virus as a gene transfer vector to the central nervous system. Gene Ther. Mar;16(3):448-52

Douglas DS, Popko B.. 2009. Mouse forward genetics in the study of the peripheral nervous system and human peripheral neuropathy. Neurochem Res. Jan;34(1):124- 37.

Ercolini, Anne M.; Miller, Stephen D.. Mechanisms of Immunopathology in Murine Models of Central Nervous System Demyelinating Disease. Journal of Immunology (2006), 3293-3298.

Schreiner, Bettina; Bailey, Samantha L.; Miller, Stephen D.. T-cell response dynamics in animal models of multiple sclerosis: implications for immunotherapies. Expert Review of Clinical Immunology (2007), 3(1): 57-72.

Traka M, Arasi K, Avila RL, Podojil JR, Christakos A, Miller SD, Soliven B, Popko B. 2010. A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination. Brain. Oct 1; 33(10):3017-29.

7. Imaging/Biomarkers

Wang Y, Wu C, Caprariello AV, Somoza E, Zhu W, Wang C, Miller RH. 2009. In vivo quantification of myelin changes in the vertebrate nervous system. J Neurosci. Nov 18;29(46):14663-9.

Wu C, Wei J, Tian D, Feng Y, Miller RH, Wang Y. 2008. Molecular probes for imaging myelinated white matter in CNS. J. Med Chem. Nov 13;51(21):6682-8 and Chemical and Engineering News: Vol.86, Issue 43, October 27, 2008, p32.